Dilaudid 8 mg (Hydromorphone) for sale.

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DILAUDID (hydromorphone hydrochloride), a hydrogenated ketone of morphine, is an opioid analgesic.

The chemical name of DILAUDID (hydromorphone hydrochloride) is 4,5(alpha)-epoxy-3-hydroxy-17-methylmorphinan-6-one hydrochloride. 

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The analgesic activity of DILAUDID (hydromorphone hydrochloride) is due to the parent drug, hydromorphone. Hydromorphone is rapidly absorbed from the gastrointestinal tract after oral administration and undergoes extensive first-pass metabolism. In vivo bioavailability following single-dose administration of the 8 mg tablet is approximately 24% (coefficient of variation 21%). Bioequivalence between the DILAUDID 8 mg TABLET and an equivalent dose of DILAUDID ORAL LIQUID has been demonstrated. Dose proportionality between DILAUDID 8 mg TABLET and other strength DILAUDID tablets (2 and 4 mg) has not been established.

Absorption:   After oral administration of DILAUDID 8 mg liquid or tablets, peak plasma hydromorphone concentrations are generally attained within 1/2 to 1-hour.

Mean (%cv)
Dosage Form
max
(ng)
max
(hrs)
AUC
(ng*hr/mL)
1/2
(hrs)
8 mg Tablet
5.5 (33%) 0.74 (34%) 23.7 (28%) 2.6 (18%)
8 mg Oral Liquid
5.7 (31%) 0.73 (71%) 24.6 (29%) 2.8 (20%)

Food effects:  The effect on the rate and extent of absorption of DILAUDID tablet or oral liquid when given with food has not been studied.